Table 2.
Association between the two polymorphisms and the risk of CRC.
| Group | Controls (%) | Cases (%) | P | OR (95%CI) |
|---|---|---|---|---|
| N = 342 | N = 329 | |||
| rs17860508 genotype | ||||
| TTAGAG/TTAGAG | 103 (30.1) | 71 (21.6) | Reference | |
| TTAGAG/GC | 166 (48.5) | 167 (50.8) | 0.045 | 1.46 (1.01–2.12) |
| GC/GC | 73 (21.3) | 91 (27.6) | 0.007 | 1.81 (1.18–2.78) |
| Allele | ||||
| TTAGAG | 372 (54.4) | 309 (47.0) | Reference | |
| GC | 312 (45.6) | 349 (53.0) | 0.007 | 1.35 (1.09–1.67) |
| rs3212227 genotype | ||||
| AA | 108 (31.6) | 96 (29.2) | Reference | |
| AC | 173 (50.6) | 160 (48.6) | 0.824 | 1.04 (0.73–1.48) |
| CC | 61 (17.8) | 73 (22.2) | 0.182 | 1.35 (0.87–2.09) |
| Allele | ||||
| A | 389 (56.9) | 352 (53.5) | Reference | |
| C | 295 (43.1) | 306 (46.5) | 0.214 | 1.15 (0.92–1.42) |
Abbreviations: CRC, colorectal cancer; OR, odds ratio; CI, confidence interval.