Figure 4.

KXS decreased Aβ42 concentration after injection in the brain (a) Aβ levels were assessed by specific ELISA with the same time interval. At t = 0, rats were injected with Aβ₄₂ directly into the hippocampus and the brains were sampled for Aβ measurement at t = 12, 24, 48, 96, 168 hours. As time went on, the injected Aβ₄₂ gradually declined in each group (^∗∗P < 0.01 vs. Aβ on identical time points; n = 8). (b) The curves of the logarithm model were used to fit the trend of Aβ₄₂ degradation. By analysis of the parameters of the two regression equations (i.e., Aβ + KXS of 15090 > Aβ of 8514), which represent the ratio of Aβ₄₂ degradation, we demonstrated that the Aβ concentration was accelerated after treatment of KXS.