Skip to main content
. 2020 Jan 14;28(3):889–900. doi: 10.1016/j.ymthe.2019.12.014

Figure 2.

Figure 2

FLT3 Bispecific Mediates In Vitro Killing of AML Cell Lines at pM Potency

(A–D) Cytotoxicity induced by healthy donor T cells against luciferase-expressing EOL-1 (A and C) and MV4-11 (B and D) cells in the presence of 7370 for 2 days at different E:T ratios as depicted. Data shown are average ± SD. (E–H) Expression of activation markers CD69 (E), 41BB (F), PD1 (G), and CD25 (H) on healthy donor CD8+ T cells at indicated time points after co-culture with EOL-1 (E:T 1:1) in the presence of 7370. Data in (A), (B), and (E)–(H) are representative of 2 donors. See also Figures S4–S6.