Figure 6.

Anti-FLT3-CD3 IgG Induces Reversible Depletion of FLT3⁺ HSPCs in Bone Marrow of Cynomolgus Monkeys

(A) Percentage of CD34⁺CD38⁺ HSPCs in the bone marrow of monkeys treated as depicted in Figure 5A. Lineage-negative cells were gated as depicted in Figure S7. (B) Flow cytometry plots showing the expression of FLT3 in CD34⁺CD38⁺ HSPCs in the bone marrow of all available monkeys at the terminal study time point. See also Figure S11.