Table 1.
Summary of ALS-8112 antiviral activity and cytotoxicity in NCI-H358 and HSAEC1-KT cells.
| Virus ID | Assay | EC50 (μM) | CC50 (μM) | SI (CC50/EC50) | |||
|---|---|---|---|---|---|---|---|
| NCI-H358 | HSAEC1-KT | NCI-H358 | HSAEC1-KT | NCI-H358 | HSAEC1-KT | ||
| NiV-M | CPE | 1.60 ± 0.07 | 2.49 ± 0.09 | > 50 | > 50 | > 31 | > 20 |
| NiV-B | CPE | 0.89 ± 0.14 | 1.29 ± 0.41 | > 56 | > 38 | ||
| VTR | ND | 0.30 | N/A | > 166 | |||
| rNiV-ZsG | REP | 0.56 ± 0.10 | 0.84 ± 0.21 | > 89 | > 59 | ||
| CPE | 2.04 ± 0.22 | 3.08 ± 0.67 | > 24 | > 14 | |||
| VTR | ND | 1.37 | N/A | > 36 | |||
| rgRSV224 | REP | 1.23 ± 0.11 | 0.36 ± 0.06 | > 40 | > 138 | ||
| rMVEZGFP(3) | REP | 41.9 ± 5.4 | 11.6 ± 8.3 | ~ 1.2 | ~ 4.3 | ||
| hPIV3-GFP | REP | > 50 | 10.8 ± 8.7 | N/A | ~ 4.6 | ||
SI- selectivity index; CPE- cytopathic effect; VTR- virus titer reduction; REP- reporter virus; ND- not determined; N/A- not applicable. EC50 values indicate the mean of at least 4 independent experiments ± standard deviation of the mean.