Table 2:
Comparison of subject demographics, pulmonary function tests, and VDP results for all participants included in the retrospective study. Results are shown separately for each institution and also as a combined dataset.
| Site #1 | Site #2 | Combined | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Healthy | CF | p Value | Healthy | CF | p Value | Healthy | CF | p Value | |
| n | 6 | 10 | - | 2 | 8 | - | 8 | 18 | - |
| Sex (males) | 3 | 3 | - | 2 | 3 | - | 5 | 6 | - |
| Age (mean ± SD) | 12.7 ± 2.6 | 13.0 ± 2.7 | 0.8945 | 13.0 ± 1.4 | 13.3 ± 1.8 | 1 | 12.7 ± 2.3 | 13.1 ± 2.3 | 0.7299 |
| FEV1 (% pred. ± SD) | 105.8 ± 21.6 | 83.8 ± 14.3 | 0.0593 | 104.5 ± 2.1 | 94.5 ± 15.7 | 0.2889 | 105.5 ± 18.3 | 85.6 ± 15.5 | 0.0636 |
| LCI (± SD) | 6.68 ± 0.47 | 11.52 ± 3.12 | 0.0017 | * | 10.39 ± 2.77 | * | 7.05 ± 0.99 | 11.10 ± 2.95 | 0.0012 |
| Analyst 1 VDP (% ± SD) | 6.55 ± 0.74 | 16.38 ± 6.15 | 0.0012 | 1.80** | 13.72 ± 7.25 | ** | 5.96 ± 1.82 | 15.96 ± 6.76 | 0.0004 |
| Analyst 2 VDP (% ± SD) | 5.76 ± 2.05 | 16.56 ± 6.90 | 0.0012 | 2.81** | 13.47 ± 6.58 | ** | 5.39 ± 2.17 | 15.48 ± 6.79 | 0.0003 |
*
LCI was not available for the healthy participants from Site #2.
**
Only one healthy individual at Site #2 had HP 129Xe images that were acceptable for analysis (SNR > 8.5).