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. 2020 Feb 3;152(3):e201912471. doi: 10.1085/jgp.201912471

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© 2020 Klipp et al.

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Figure 2. — STOM inhibition of ASIC3 involves the C-terminus, but not TM2. (A) Cartoon showing swap of ASIC3's C-terminus (residues 466–533) with ASIC1a's C-terminus (residues 459–526) is named ASIC3(466–533)1a. (B and C) Left: Cartoon depicting the chimera being examined. Middle: Representative pH 5.5–evoked currents of the indicated chimeric channel alone (black) and cotransfected with STOM (red). Right: Boxplots of the current density measurements for the chimeric channel with and without STOM. Average current densities for ASIC3(436–533)1a in the absence (black) and presence (red) of STOM were 205.3 ± 50.6 pA/pF (n = 12) and 337.1 ± 109.0 pA/pF (n = 10), respectively. Average current densities for ASIC3(436–465)1a in the absence (black) and presence (red) of STOM were 15.4 ± 4.9 pA/pF (n = 9) and STOM mean 0 ± 0 pA/pF (n = 9), respectively. Data are given as mean ± SEM.