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. 2020 Jan 29;152(3):e201912442. doi: 10.1085/jgp.201912442

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© 2020 Thompson et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 10. — Neuronal maturity influences hyperexcitability associated with Na_V1.2 variants. (A) Action potentials generated in response to a 2.2-nA somatic current stimulation for an immature neuron expressing 67% Na_V1.2N and 33% Na_V1.2A throughout the AIS (left), an immature neuron expressing 67% Na_V1.2N and 33% Na_V1.2A throughout the AIS, and lower potassium conductance (middle), and a mature neuron expressing 33% Na_V1.2N and 67% Na_V1.2A restricted to the proximal AIS (right). (B) Summary data plotting the number of action potentials against stimulation current for the immature neuron defined in A. (C) Summary data plotting the number of action potentials against stimulation current for the immature neuron with low potassium conductance defined in A. (D) Summary data plotting the number of action potentials against stimulation current for the mature neuron defined in A. All simulations assumed heterozygosity.