Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 29;152(3):e201912442. doi: 10.1085/jgp.201912442

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Thompson et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 2. — Function of EOEE-associated variants. (A) Predicted transmembrane topology of Na_V1.2, highlighting the location of the exon 5 coding region (black shaded), amino acid change associated with alternative exon splicing (black dot), and EOEE-associated variants (colored dots). (B) Whole-cell sodium currents of EOEE-associated Na_V1.2 variants in either the adult (Na_V1.2N; left) or neonatal (Na_V1.2A; right) splice isoforms. (C) Peak current density elicited by test pulses to 0 mV from a holding potential of −120 mV for Na_V1.2N (open bars) and Na_V1.2A (closed bars) proteoforms. All data are expressed as mean ± SEM for 8–15 measurements. *, P < 0.05 compared with Na_V1.2A; ^‡, P < 0.05 Na_V1.2N. EOEE-associated variants were compared with WT Na_V1.2 of the same proteoform using a one-way ANOVA, followed by Dunnett’s post hoc test.