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. 2020 Jan 29;152(3):e201912442. doi: 10.1085/jgp.201912442

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© 2020 Thompson et al.

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Figure 4. — Alternative splicing of Na_V1.2 differentially modulates the effect of EOEE-associated variants on channel activation. (A and B) Voltage dependence of activation for WT and EOEE-associated Na_V1.2 variants in the neonatal (A) or adult (B) proteoform. (C and D) Values for V_1/2 of activation for WT and EOEE-associated Na_V1.2 variants in the neonatal (C) or adult (D) proteoform. All data are expressed as mean ± SEM for 8–15 measurements. EOEE-associated variants were compared with WT Na_V1.2 of the same proteoform using one-way ANOVA, followed by Dunnett’s post hoc test. ***, P < 0.0001; **, P < 0.01; *, P < 0.05.