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. 2020 Jan 29;152(3):e201912442. doi: 10.1085/jgp.201912442

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© 2020 Thompson et al.

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Figure 8. — Computational modeling of WT Na_V1.2 splice isoforms. (A) Simulated whole-cell sodium current for Na_V1.2A (top) and Na_V1.2N (bottom). (B) Voltage dependence of activation and inactivation for simulated sodium currents mediated by the Na_V1.2N (open circles) and Na_V1.2A (closed circles). Curves for voltage dependence of inactivation for both isoforms are superimposed. (C) Radar plots comparing changes in biophysical parameters of whole-cell sodium current from simulated data for Na_V1.2N (left) and Na_V1.2A (right).