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. 2020 Jan 29;152(3):e201912442. doi: 10.1085/jgp.201912442

Table 1. Biophysical properties of NaV1.2 variants.

Variant Voltage dependence of activation Voltage dependence of fast inactivation Recovery from fast inactivation (−10 mV)
V1/2 (mV) k (mV) n V1/2 (mV) k (mV) n τf (ms) (amplitude) τs (ms) (amplitude) n
NaV1.2A −23.5 ± 1.3 6.3 ± 0.3 15 −63.5 ± 0.9 −6.2 ± 0.1 15 1.9 ± 0.1 (0.90 ± 0.01) 275.6 ± 16.4 (0.12 ± 0.01) 15
NaV1.2A-T236S −25.6 ± 2.0 7.0 ± 0.3 9 −65.3 ± 1.8 −5.6 ± 0.1 9 2.1 ± 0.1 (0.87 ± 0.01) 270.1 ± 16.8 (0.14 ± 0.01) 8
NaV1.2A-E999K −4.6 ± 1.4 6.5 ± 0.3 10 −63.1 ± 1.2 −6.2 ± 0.1 10 1.9 ± 0.2 (0.90 ± 0.01) 269.3 ± 21.2 (0.14 ± 0.01) 10
NaV1.2A-S1336Y −23.2 ± 1.4 7.9 ± 0.4 11 −57.7 ± 1.3a −6.6 ± 0.3 11 1.3 ± 0.2 (0.84 ± 0.03) 210.3 ± 20.4 (0.21 ± 0.02) 11
NaV1.2A-T1623N −18.4 ± 1.4a 6.4 ± 0.6 8 −56.7 ± 0.8a −6.0 ± 0.1 8 2.1 ± 0.1 (0.92 ± 0.01) 240.4 ± 17.4 (0.09 ± 0.01) 8
NaV1.2A-R1882Q −19.5 ± 0.9 6.7 ± 0.3 15 −51.2 ± 1.5a −7.6 ± 0.3a 15 1.6 ± 0.1 (0.84 ± 0.02) 248.2 ± 22.0 (0.16 ± 0.02) 15
NaV1.2N −19.5 ± 0.8b 7.0 ± 0.3 15 −62.4 ± 1.2 −6.4 ± 0.1 15 1.7± 0.1 (0.90 ± 0.01) 267.3 ± 28.8 (0.13 ± 0.01) 15
NaV1.2N-T236S −29.9 ± 1.1a 5.7 ± 0.4a 15 −62.3 ± 0.8 6.1 ± 0.4 8 1.9 ± 0.1 (0.87 ± 0.01) 245.3 ± 7.7 (0.14 ± 0.01) 7
NaV1.2N-E999K −26.2 ± 1.7a 6.3 ± 0.4 14 −63.1 ± 1.3 −5.8 ± 0.1 13 1.8 ± 0.1 (0.89 ± 0.01) 263.2 ± 22.9 (0.12 ± 0.01) 13
NaV1.2N-S1336Y −25.3 ± 1.9a 7.3 ± 0.7 10 −56.9 ± 1.0a −7.9 ± 0.8a 10 1.0 ± 0.1 (0.89 ± 0.02) 261.0 ± 38.8 (0.16 ± 0.03) 10
NaV1.2N-T1623N −18.4 ± 1.4 6.2 ± 0.3 9 −56.3 ± 0.7a −6.3 ± 0.4 9 2.0 ± 0.1 (0.87 ± 0.02) 213.6 ± 23.9 (0.14 ± 0.02) 9
NaV1.2N-R1882Q −20.6 ± 1.7 6.2 ± 0.4 14 −53.4 ± 1.3a −7.0 ± 0.2a 14 1.6 ± 0.1 (0.88 ± 0.02) 258.2 ± 27.8 (0.12 ± 0.02) 14
a

P < 0.05 between WT and variant in same splice isoform.

b

P < 0.05 between neonatal and adult isoforms.