Figure 3.

Mutant alleles at LATE3 and LATE4 loci carry mutations in genes encoding Mediator complex components CYCLIN-DEPENDENT KINASE8 and CYCLIN C1, respectively. Diagrams showing (A) gene structure of PsCDK8 and the nature and location of mutations in late3 alleles and (B) gene structure of PsCYCC1 and the nature and location of mutations in late4 alleles. Exons are represented by numbered boxes, with gray shading designating 5′ and 3′ UTRs. Dashed lines in A represent introns not fully characterized. Sequence details of mutations and splice variants are shown in Supplemental Figs. S9, S12, and S13.