Figure 4.

mEPSCs and intrinsic properties of PV INs are not altered in Disc1 LI mice. A, Recording configuration and sample mEPSC traces recorded from PV INs in WT (upper) and Disc1 LI mice (lower). B, Mean mEPSC amplitude (left) and median frequency (right; n = 20, 23 cells/genotype; N = 4 mice/genotype). C, Sample traces from whole-cell current clamp recording of L2/3 PV IN in WT (left) and Disc1 LI mouse in response to current injections. D, Input-output curve showing average firing rate of PV INs in response to current injection in WT versus Disc1 LI. E, Resting membrane potential. F, Input resistance. G, Current threshold required to elicit spiking. H, Maximum firing rate. Data in D, E, H shown as mean ± SEM. Data in F, G shown as median ± interquartile range.