Table 3.
Expression of novel SCC markers. Sensitivity, specificity, percentage of true positives and percentage of true negatives, accuracy, Youden’s J statistic, and positive and negative likelihood ratio values for PKP1, KRT15, and DSG3 staining according to their nuclear, cytoplasmic, or membranous localization.
| PKP1 |
KRT15 |
DSG3 |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Nucleus | Cytoplasm | Membrane | Nucleus | Cytoplasm | Membrane | Nucleus | Cytoplasm | Membrane | |
| Sensitivity (%) (positive/total)a | 72.1 (31/43) | 86 (37/43) | 76.7 (33/43) | 19.5 (8/41) | 73.2 (30/41) | 75.6 (31/41) | 16.7 (7/42) | 61.9 (26/42) | 64.3 (27/42) |
| Specificity (%) (positive/total)b | 92.3 (36/39) | 82.1 (32/39) | 97.4 (38/39) | 73 (27/37) | 94.6 (35/37) | 94.6 (35/37) | 89.7 (35/39) | 94.9 (37/39) | 100 (39/39) |
| PTP (%) (positive/total)c | 91.2 (31/34) | 84.1 (37/44) | 97.1 (33/34) | 44.4 (8/18) | 93.8 (30/32) | 93.9 (31/33) | 63.6 (7/11) | 92.9 (26/28) | 100 (27/27) |
| PTN (%) (positive/total)d | 75 (36/48) | 84.2 (32/38) | 79.2 (38/48) | 45 (27/60) | 76.1 (35/46) | 77.8 (35/45) | 50 (35/70) | 69.8 (37/53) | 72.2 (39/54) |
| Accuracy (%) (positive/total)e | 81.7 (67/82) | 84.1 (69/82) | 86.6 (71/82) | 44.9 (35/78) | 83.3 (65/78) | 84.6 (66/78) | 51.9 (42/81) | 77.8 (63/81) | 81.5 (66/81) |
| Youden’s J statisticf | 0.64 | 0.68 | 0.74 | −0.08 | 0.68 | 0.70 | 0.06 | 0.57 | 0.643 |
| LR+g | 9.36 | 4.80 | 29.50 | 0.72 | 13.56 | 14.00 | 1.62 | 12.14 | – |
| LR−h | 0.30 | 0.17 | 0.24 | 1.10 | 0.28 | 0.26 | 0.93 | 0.40 | 0.357 |
Sensitivity = TP/(TP + FN).
Specificity = TN/(TN + FP).
PTP = TP/(TP + FP).
PTN = TN/(TN + FN).
Accuracy = (TP + TN)/(TP + FP + FN + TN).
Youden’s J statistic = Sensitivity + Specificity-1.
Positive LR (LR+) = Sensitivity/(1-Specificity).
Negative LR (LR-) = (1-Sensitivity)/Specificity.
FN: false negatives; FP: false positives; LR: likelihood ratio; PTN: percentage of true negatives; PTP: percentage of true positives; TN: true negatives; TP: true positives.