Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model of the CRED pathway. Stresses induce the generation of extracellular aberrant proteins, which selectively interact with Clusterin. Positively charged residues on Clusterin electrostatically bind to the negatively charged HS chain on proteoglycan. The Clusterin–protein complex on the HS chain is then delivered into the lysosome via endocytosis and is digested into amino acids.
