Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 20;219(3):e202001159. doi: 10.1083/jcb.202001159

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Sánchez-Martín and Komatsu

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 1. — Model of the CRED pathway. Stressors induce the misfolding of extracellular proteins. These aberrant proteins are recognized by the chaperon clusterin. Cargo-bound clusterin can interact then with heparan sulfate proteoglycans in the surface of the cells to undergo endocytosis and finally be degraded in the lysosome.