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. 2020 Mar 4;13:30. doi: 10.1186/s13041-020-00569-6

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© The Author(s) 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — ADDL-induced increase in nitric oxide level in astrocytic cells is inhibited by sinomenine. The C8D1A astrocytic cells were treated with oligomeric amyloid beta (ADDL) in the absence or presence of sinomenine and the levels of nitric oxide (NO) were assessed. ADDL treatment increased NO level in the cells. However, sinomenine inhibited the ADDL-induced increase in the NO level (n = 4). Sinomenine did not affect NO level in the cells in the absence of ADDL treatment. Asterisk indicates significant difference from control (p < 0.05). # indicates significant difference (p < 0.05) between groups as indicated