| Methods |
Randomized, double blind, placebo‐controlled trial |
| Participants |
Enrolled 186 children ages 1.5 to 24 months, treated as outpatients in a pediatric ED. Mean age 9.5 months, 65.1% male. Inclusion criterion was mild bronchiolitis (clinical score between 1 and 9). Exclusions were prior history of wheezing, previous treatment with bronchodilators and/or steroids and lung or cardiac disease
Country: Turkey |
| Interventions |
All groups were pre‐treated with 8 ml of nebulized normal saline. Treatment was 2.5 mg of salbutamol in 4 ml of 0.9% saline at 0 and 30 minutes. The placebo group received a 4 ml 0.9% saline solution nebulization. 2 other study groups received epinephrine |
| Outcomes |
Clinical score (RDAI), pulse oximetry and heart rate at 0, 30, 60 and 120 minutes, and hospital admission |
| Notes |
All participants were reassessed for recurrent wheezing attacks in the following 6 months (by phone) |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
|
| Allocation concealment (selection bias) |
Low risk |
|
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
|
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
|
| Selective reporting (reporting bias) |
Low risk |
|
