Wang 1992.
| Methods | Randomized, double‐blind, factorial trial | |
| Participants | Setting: inpatients Infants 2 to 24 months of age hospitalized for the first time with mild bronchiolitis. 55% male, no underlying cardiac/lung disease Country: Canada | |
| Interventions | Group 1: salbutamol at 0.15 mg/kg/dose in 2 ml saline followed 1 hour later by 0.5 ml or 1 ml saline placebo. Group 2: 0.03 ml/kg saline in 2 ml saline followed by either 125 µg ipratropium bromide if less than 6 months old or 250 µg ipratropium bromide if older than 6 months. Group 3: both salbutamol and ipratropium bromide in doses indicated. Group 4: saline placebos in same volumes indicated | |
| Outcomes | Oxygen saturation, study‐specific clinical assessment (4‐point score for each of respiratory rate, wheezing, retractions, general condition) | |
| Notes | Infants with prior use of bronchodilators were included (1 in salbutamol, 2 in ipratropium, 4 in saline). 4 participants withdrawn from trial due to worsening: 1 in Group 1, 2 in Group 3 and 1 in Group 4 | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | |
| Allocation concealment (selection bias) | Low risk | |
| Blinding (performance bias and detection bias) All outcomes | Low risk | |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | |
| Selective reporting (reporting bias) | Low risk | |
CBSS = clinical bronchiolitis severity score CXR = chest X‐ray ED = emergency department HR = heart rate hr = hour HS = hypertonic saline ICU = intensive care unit IM = intramuscular IV = intravenous L/min = liters per minute MDI = metered dose inhaler NS = normal saline RACS = Respiratory Assessment Change Score RDAI = Respiratory Distress Assessment Instrument RDI = Respiratory Distress Index RDS = Respiratory Distress Score RR = respiratory rate RSV = respiratory syncytial virus SpO2 = oxygen saturation URI = upper respiratory infection WARI = wheeze associated acute respiratory infection