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. 2019 Jan 20;2019(1):CD001324. doi: 10.1002/14651858.CD001324.pub6

Comparison 25. Mifepristone high dose (> 50 mg) versus mifepristone mid dose (25‐50 mg).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Observed number of pregnancies (all women) 9 3009 Risk Ratio (M‐H, Fixed, 95% CI) 0.93 [0.50, 1.72]
2 Any side effect 5 1310 Risk Ratio (M‐H, Random, 95% CI) 2.64 [1.57, 4.43]
3 Specific side effects 5   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
3.1 Nausea 1 90 Risk Ratio (M‐H, Fixed, 95% CI) 1.25 [0.36, 4.35]
3.2 Dizziness 1 90 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.21, 4.69]
3.3 Fatigue 1 90 Risk Ratio (M‐H, Fixed, 95% CI) 2.0 [0.19, 21.28]
3.4 Breast tenderness 1 90 Risk Ratio (M‐H, Fixed, 95% CI) 2.0 [0.19, 21.28]
3.5 Diarrhoea 1 90 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.21, 4.69]
3.6 Spotting/bleeding after treatment 4 1509 Risk Ratio (M‐H, Fixed, 95% CI) 1.32 [1.12, 1.56]
4 Menses 8   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
4.1 Early 2 290 Risk Ratio (M‐H, Fixed, 95% CI) 10.0 [1.30, 76.66]
4.2 Delay 8 2854 Risk Ratio (M‐H, Fixed, 95% CI) 1.53 [1.34, 1.75]