Table 4.
Analgesic use according to the experience of bone complications
| Outcome | At-risk perioda | Patient population | EU5b N = 813 |
France N = 146 |
Germany N = 175 |
Italy N = 173 |
Spain N = 141 |
UK N = 173 |
|---|---|---|---|---|---|---|---|---|
| Patients who received analgesics by at-risk period, n (%)c | ||||||||
| Any analgesic use | Overall | All patients | 461 (57) | 102 (70) | 110 (63) | 84 (49) | 94 (67) | 66 (38) |
| With BCs | 162 (76) | 36 (90) | 34 (71) | 35 (71) | 25 (86) | 27 (63) | ||
| Without BCs | 299 (50) | 66 (62) | 76 (60) | 49 (40) | 69 (62) | 39 (30) | ||
| Period 2 | All patients | 457 (56) | 104 (71) | 110 (63) | 84 (49) | 93 (66) | 60 (35) | |
| With BCs | 160 (75) | 34 (85) | 35 (73) | 33 (67) | 26 (90) | 28 (65) | ||
| Without BCs | 296 (49) | 70 (66) | 75 (59) | 51 (41) | 67 (60) | 32 (25) | ||
| Period 3 | All patients | 234 (29) | 43 (30) | 66 (38) | 46 (27) | 10 (7) | 32 (19) | |
| With BCs | 89 (42) | 15 (38) | 21 (44) | 22 (45) | 21 (72) | 13 (30) | ||
| Without BCs | 145 (24) | 28 (26) | 45 (35) | 24 (19) | 31 (28) | 19 (15) | ||
| Patients who received analgesics by stepc and at-risk period, n (%)d | ||||||||
| Step 1 | Overall | All patients | 255 (31) | 38 (26) | 70 (40) | 56 (32) | 51 (36) | 47 (27) |
| Step 2 | 192 (24) | 46 (32) | 50 (29) | 30 (17) | 36 (26) | 25 (15) | ||
| Step 3 | 162 (20) | 51 (35) | 37 (21) | 21 (12) | 34 (24) | 10 (6) | ||
| Step 1 | With BCs | 73 (34) | 11 (28) | 18 (38) | 21 (43) | 9 (31) | 14 (33) | |
| Step 2 | 72 (34) | 15 (38) | 11 (23) | 16 (33) | 12 (41) | 16 (37) | ||
| Step 3 | 72 (34) | 21 (53) | 18 (38) | 10 (20) | 12 (41) | 7 (16) | ||
| Step 1 | Without BCs | 182 (30) | 27 (26) | 52 (41) | 35 (28) | 42 (38) | 33 (25) | |
| Step 2 | 120 (20) | 31 (29) | 39 (31) | 14 (11) | 24 (21) | 9 (7) | ||
| Step 3 | 89 (15) | 30 (28) | 19 (15) | 11 (9) | 22 (20) | 3 (2) | ||
| Step 1 | Period 2 | All patients | 216 (27) | 30 (21) | 63 (36) | 50 (29) | 36 (26) | 41 (24) |
| Step 2 | 165 (20) | 39 (27) | 49 (28) | 23 (13) | 31 (22) | 19 (11) | ||
| Step 3 | 144 (18) | 46 (32) | 33 (19) | 18 (10) | 32 (23) | 8 (5) | ||
| Step 1 | With BCs | 65 (30) | 8 (20) | 16 (33) | 18 (37) | 8 (28) | 16 (37) | |
| Step 2 | 62 (29) | 14 (35) | 12 (25) | 12 (24) | 9 (31) | 13 (30) | ||
| Step 3 | 59 (28) | 16 (40) | 16 (33) | 7 (14) | 11 (38) | 6 (14) | ||
| Step 1 | Without BCs | 150 (25) | 22 (21) | 47 (37) | 32 (26) | 28 (25) | 25 (19) | |
| Step 2 | 102 (17) | 25 (24) | 37 (29) | 11 (9) | 22 (20) | 6 (5) | ||
| Step 3 | 86 (14) | 30 (28) | 17 (13) | 11 (9) | 21 (19) | 2 (2) | ||
| Step 1 | Period 3 | All patients | 130 (16) | 17 (12) | 39 (22) | 30 (17) | 52 (37) | 21 (12) |
| Step 2 | 82 (10) | 14 (10) | 27 (15) | 15 (9) | 30 (21) | 13 (8) | ||
| Step 3 | 56 (7) | 15 (10) | 17 (10) | 7 (4) | 13 (9) | 5 (3) | ||
| Step 1 | With BCs | 40 (19) | 5 (13) | 9 (19) | 15 (31) | 7 (24) | 6 (14) | |
| Step 2 | 33 (15) | 3 (8) | 8 (17) | 8 (16) | 8 (28) | 8 (19) | ||
| Step 3 | 33 (16) | 3 (8) | 8 (17) | 4 (8) | 7 (24) | 4 (9) | ||
| Step 1 | Without BCs | 90 (15) | 12 (11) | 30 (24) | 15 (12) | 23 (21) | 15 (12) | |
| Step 2 | 49 (8) | 11 (10) | 19 (15) | 7 (6) | 5 (5) | 5 (4) | ||
| Step 3 | 23 (4) | 6 (6) | 9 (7) | 3 (2) | 3 (3) | 1 (1) | ||
BCs bone complications, EU5 five European countries (France, Germany, Italy, Spain and the UK), UK United Kingdom
aOverall: from multiple myeloma diagnosis to disease progression following first-line treatment; period 2: during active first-line therapy; period 3: after treatment discontinuation. Note that analgesic use was not recorded for period 1 (before initiation of induction therapy)
bAggregated EU5 data have been weighted based on the multiple myeloma incidence in each country so base sizes for individual countries may not equal the EU5 total
cStep on the World Health Organization analgesic ladder
dExpressed as a percentage of the total number of patients, patients with BCs or patients without BCs, as indicated (patient numbers by country – EU5 with BCs: 214; EU5 without BCs: 599; France with BCs: 40; France without BCs: 106; Germany with BCs: 48; Germany without BCs: 127; Italy with BCs: 49; Italy without BCs: 124; Spain with BCs: 29; Spain without BCs: 112; UK with BCs: 43; UK without BCs: 130)