Fig. 3.

Induction of mitophagy by PD via activation of SIRT1. The mice were subjected to CLP, administered vehicle, PD (30 mg/kg), or PD plus EX527 (10 mg/kg). a Parkin levels in the mitochondrial and cytosolic fractions of renal cells were assessed by western blot analysis. Quantification of b mitochondrial and c cytoplasmic Parkin levels. d The levels of the mitochondrial markers TOM20 and TIM23 were measured by western blot analysis. Quantification of e TOM20 and f TIM23