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. 2020 Mar 4;19:107. doi: 10.1186/s12936-020-03176-x

Table 1.

The pfdhfr/pfdhps haplotypes and pfgch1 copy number variation of P. falciparum separated by Thailand-neighboring countries between 2008 and 2016

Area Yeara DHFR DHPS GCH1 Num.
A16V C50R N51I C59R S108N I164L A/S436F A437G K540E/N A581G A613S/T Single/Multiple
Thailand-Myanmar border 2008–2010 A C N R N L A/S G E A A S 3
A C N R N L A/S G E G A S 1
A C I R N I A/S G E A A M 1
A C I R N L A/S G E A A S 4
A C I R N L A/S G E A A M 6
A C I R N L A/S G E G A S 12
A C I R N L A/S G E G A M 6
A C I R N L F G E A T S 2
2011–2013 A C N R N I A/S G E G A M 1
A C N R N L A/S G E G A S 1
A C I R N I A/S G E A A S 1
A C I R N I A/S G E A A M 1
A C I R N I A/S G E G A S 1
A C I R N I A/S G E G A M 5
A C I R N I A/S G K A A S 2
A C I R N L A/S G E A A S 11
A C I R N L A/S G E A A M 4
A C I R N L A/S G E G A S 19
A C I R N L A/S G E G A M 17
A C I R N L A/S G N G A M 1
A C I R N L F G E A T S 1
A C I R N L F G E A T M 1
A C I R N L F G E G A S 1
A C I R N L F G E G A M 5
2014–2016 A C I R N I A/S G E A A S 2
A C I R N I A/S G E A A M 1
A C I R N I A/S G K A A S 2
A C I R N L A/S G E A A S 4
A C I R N L A/S G E A A M 12
A C I R N L A/S G E G A S 5
A C I R N L A/S G E G A M 10
Total 146
Thailand–Cambodia border 2008–2010 A C I R N I A/S G E A A S 1
A C I R N I A/S G N G A S 2
A C I R N L A/S G E A A S 2
A C I R N L A/S G E A A M 1
A C I R N L A/S G N G A S 6
2014–2016 A C I R N I A/S G E A A S 5
A C I R N I A/S G K A A S 1
A C I R N I A/S G K A A M 1
A C I R N L A/S G E A A S 1
A C I R N L A/S G N G A S 19
A C I R N L A/S G N G A M 1
Total 40
Thailand–Malaysia border 2008–2010 A C I R N I A/S G K A A S 2
A C I R N L A/S G K A A S 1
2011–2013 A C I R N I A/S G K A A S 7
2014–2016 A C I R N I A/S G K A A S 13
A C I R N I A/S G K G A M 5
A C I R N I A/S G K G A S 19
Total 47

Each italic upper script letters represent mutation observed in the amino acid at the corresponding position

aThe mutations observed are grouped based on year of sample collection