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. 2020 Mar 4;19:51. doi: 10.1186/s12943-020-01174-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Validation of MIR22HG expression in independent datasets. a-c, The distribution of MIR22HG expression in three independent datasets. d-e, Kaplan-Meier overall survival curves (d) and disease-free survival curves (e) are presented. All patients were divided into two groups based on the expression of MIR22HG. Red, high expression of MIR22HG and green, low expression of MIR22HG. f, The expression of MIR22HG in 163 normal and tumor samples. g, The expression of MIR22HG in 21 normal, tumor and metastasis Chinese samples. h, Kaplan-Meier overall survival of Chinese CRC patients based on expression of MIR22HG