Table 2.

Functional roles of 10 hub genes

No.	Gene symbol	Full name	Function
1	CDK1	Cyclin-dependent kinase 1	Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset
2	CDC20	Cell division cycle protein 20 homolog	Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome and may confer substrate specificity upon the complex
3	AURKA	Aurora kinase A	Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression.
4	PLK1	Polo-like kinase 1	Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle
5	AURKB	Aurora kinase B	Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis
6	CDC6	Cell division control protein 6 homolog	Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated
7	KIF11	Kinesin family member 11	Motor protein required for establishing a bipolar spindle during mitosis. Required in nonmitotic cells for transport of secretory proteins from the Golgi complex to the cell surface
8	CCNA2	Cyclin A2	Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle
9	CENPE	Centromere-associated protein E	Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation, and spindle assembly checkpoint activation
10	MKI67	Marker of proliferation Ki-67	Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly