Fig. 8.

hiPSC-RPE preserved the photoreceptor function in rd10 mice. a, b Representative typical dark-adapted and light dark-adapted ERG response from rd10 at P26 after hiPSC-REP transplantation. Non-transplantation rd10 mice, WT, and WT-sham at the same age are used as a comparison. c Average scotopic a- and b-wave amplitudes elicited at 0.03, 0.3, 1, and 10 cd-s/m² light intensities. d Average photopic a-wave and b-wave amplitudes elicited at 1, 3, and 10 cd-s/m² light intensities. Results show that both under dark-adapted and light dark-adapted conditions, the ERG a-wave and b-wave amplitudes were significantly higher in the hiPSC-RPE-treated group than rd10 without transplantation. WT and WT-sham (injected with PBS) group ERG responses were not significant. Data are presented as mean ± SEM. p values were determined by one-way ANOVA followed by Dunnett’s T3 multiple comparison tests (c, d). n = 6 for each group. *p < 0.05, **p < 0.01