Table 2.
Rating scale assessments
| Rating scale | |
|---|---|
| UPDRS Part I (mentation, behavior and mood); mean ± SD | |
| Baseline (n = 477) | 2.3 ± 2.1 |
| 3 months (n = 393) | 1.9 ± 1.9 |
| Change from baseline (n = 393) | − 0.3 ± 1.5 |
| UPDRS Part II (ADL during OFF); mean ± SD | |
| Baseline (n = 476) | 17.1 ± 7.0 |
| 3 months (n = 391) | 13.9 ± 6.8 |
| Change from baseline (n = 391) | − 3.0 ± 4.6 |
| P value vs. baseline | < 0.0001 |
| UPDRS Part III (motor scores during ON); mean ± SD | |
| Baseline (n = 477) | 26.5 ± 12.1 |
| 3 months (n = 393) | 21.5 ± 11.0 |
| Change from baseline (n = 393) | − 4.6 ± 8.1 |
| P value vs. baseline | < 0.0001 |
| UPDRS Total scores (Part II + III); mean ± SD | |
| Baseline (n = 477) | 37.5 ± 16.9 |
| 3 months (n = 393) | 30.5 ± 15.2 |
| Change from baseline (n = 393) | − 6.4 ± 10.4 |
| P value vs. baseline | < 0.0001 |
| UPDRS Part IV (complications of therapy); mean ± SD | |
| Baseline (n = 475) | 5.2 ± 2.6 |
| 3 months (n = 391) | 4.2 ± 2.4 |
| Change from baseline (n = 391) | − 0.8 ± 1.9 |
| PDQ-8 Total Score; mean ± SD | |
| Baseline (n = 476) | 29.2 ± 16.4 |
| 3 months (n = 393) | 25.2 ± 15.8 |
| Change from baseline (n = 393) | − 3.4 ± 12.8 |
| P value vs. baseline | < 0.0001 |
| NMSS Score; mean ± SD | |
| Baseline (n = 477) | 44.6 ± 30.3 |
| 3 months (n = 393) | 37.0 ± 26.7 |
| Change from baseline (n = 393) | − 6.8 ± 19.7 |
| P value vs. baseline | < 0.0001 |
NMSS Non-motor symptom scale, UPDRS Unified Parkinson’s Disease Rating Scale, PDQ-8 Parkinson’s Disease Questionnaire