Table 1.
Improvement in parkinsonian motor signs during acute STN and GPi DBS
| Subject | Motor sign | mUPDRS baseline | STN-DBS improvement, % | GPi-DBS improvement, % |
|---|---|---|---|---|
| K | Rigidity | 2.0 (2.0,2.2) | 53 (53,58) | 50 (44,54) |
| Tremor | 0.5 (0.5,0.5) | 100 (100,100) | 100 (100,100) | |
| Bradykinesia | 2.5 (2.0,3.0) | 50 (50,50) | 42 (33,50) | |
| Akinesia | 2.5 (2.0,3.0) | 50 (50,50) | 50 (50,50) | |
| Food retrieval | 2.5 (2.5,2.5) | 50 (35,62) | 40 (40,40) | |
| J | Rigidity | 0.9 (0.9,1.1) | 47 (37,55) | 47 (40,54) |
| Tremor | 0.0 (0.0,0.0) | NA | NA | |
| Bradykinesia | 2 (1.5,2) | 33 (25,50) | 33 (25,50) | |
| Akinesia | 2 (1.5,2) | 33 (25,50) | 33 (25,50) | |
| Food retrieval | 2 (1.5,2) | 25 (25,33) | 33 (25,35) |
Values are medians (1st quartile, 3rd quartile). mUPDRS for NHPs was used to assess motor signs in each animal, rating upper limb rigidity, tremor, bradykinesia, akinesia, and food retrieval (on the arm contralateral to neural recordings) using a 0–3 scale (0 = normal, 3 = severe). Baseline Off-DBS scores are shown, as are percentage improvement observed with STN and GPi DBS. Number of observations: Subject K, baseline n = 23, Off- versus STN DBS and Off- versus GPi DBS within-session comparisons n = 10 and 6, respectively. Subject J, baseline n = 38, Off- versus STN DBS and Off versus GPi DBS within-session comparisons n = 17 for each. There was no significant difference between median percentage improvement in motor signs with STN versus GPi DBS in either animal (Wilcoxon rank sum, p > 0.05, since all p values were above 0.05.