Table 2.
Clinical ratings of parkinsonian animals before, during and after subacute STN DBS
| On-DBS |
Post-DBS |
Highest improvement with DBS, % | ||||||
|---|---|---|---|---|---|---|---|---|
| Subject | Motor sign (highest possible score) | Pre-DBS | 1 h | 2 h | 3 h | 30 min | 60 min | |
| K | *Rigidity (6) | 6.0 (4.8,6.0) | 3.5 (3.5,4.0) | 3.5 (3.5,4.3) | 3.5 (3.5,3.8) | 5.0 (4.8,5.8) | 5.5 (5.0,6.0) | 42 |
| Tremor (6) | 0.5 (0.3,0.5) | 0.5 (0.3,0.5) | 0.5 (0.3,0.5) | 0.5 (0.5,0.5) | 0.5 (0.5,0.5) | 0.5 (0.5,0.5) | 0 | |
| *Bradykinesia (6) | 5.0 (5.0,5.5) | 3.5 (3.0,3.5) | 3.5 (3.0,3.5) | 3.5 (3.5,3.5) | 5.0 (4.3,5.0) | 4.5 (4.5,5.0) | 30 | |
| *Akinesia (6) | 5.5 (5.5,5.5) | 3.0 (2.5,3.3) | 3.0 (2.8,3.8) | 3.0 (2.8,3.8) | 4.5 (4.0,5.3) | 5.0 (5.0,5.5) | 45 | |
| *Food retrieval (3) | 2.5 (2.5,2.5) | 1.5 (1.0,1.5) | 1.5 (1.0,1.5) | 1.5 (1.0,2.0) | 2.5 (2.5,2.5) | 2.5 (2.5,2.5) | 40 | |
| J | *Rigidity (6) | 2.2 (2.1,2.3) | 1.5 (1.1,1.6) | 1.3 (1.1,1.3) | 1.2 (1.1,1.3) | 1.9 (1.8,2.0) | 2.1 (2.0,2.1) | 45 |
| Tremor (6) | 0.0 (0.0,0.0) | 0.0 (0.0,0.0) | 0.0 (0.0,0.0) | 0.0 (0.0,0.0) | 0.0 (0.0,0.0) | 0.0 (0.0,0.0) | 0 | |
| *Bradykinesia (6) | 4.0 (3.8,4.0) | 3.0 (2.8,3.5) | 2.5 (2.5,3.5) | 3.5 (2.5,3.5) | 4.0 (3.8,4.0) | 4.0 (3.6,4.0) | 38 | |
| *Akinesia (6) | 4.0 (4.0,4.0) | 2.5 (2.5,3.3) | 3.0 (2.3,3.0) | 3.0 (2.5,3.3) | 4.0 (3.5,4.0) | 4.0 (3.6,4.0) | 38 | |
| Food retrieval (3) | 2.0 (2.0,3.0) | 2.0 (1.5,2.3) | 2.0 (1.5,2.3) | 1.5 (1.5,2.3) | 2.5 (1.8,2.5) | 2.3 (1.6,2.5) | 25 | |
Values are medians (1st quantile, 3rd quantile). The number of assessments was five for each condition except for the values in italic, which were four. On DBS ratings were not taken in Hour 4.
* p < 0.05, Wilcoxon test. Bold scores are significantly different from its Pre-DBS condition in Steel's test with control = Pre-DBS.