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. 2020 Mar 4;40(10):2154–2165. doi: 10.1523/JNEUROSCI.2212-19.2020

Figure 3.

Figure 3.

HN treatment reduces neurological deficits and improves hematoma clearance in an ICH mouse model, suggesting a role of phagocytic cells. NDSs were calculated from corner, postural flexing, or foot-fault testing in mice treated either with HN given intraperitoneally (1 μg/g) (A,B) or intranasally (1 μg/g) (D) starting 1 h (A,B) or 3 h (D) after ICH onset. PBS was used as a vehicle control. C, Hemoglobin content as an index of hematoma clearance in ICH-affected brains on day 7 after ICH in mice treated with intraperitoneal HN or PBS. Data are mean ± SEM. A, Two-way ANOVA/Fisher's LSD test, n = 8 per group, *p < 0.05 (p = 0.0271), t values (t = 2.275). B, Two-way ANOVA/Fisher's LSD test, n = 8 per group, *p < 0.05 (p = 0.0299), t values (t = 2.232) at day 7; *p < 0.05 (p = 0.0455), t values (t = 2.049) at day 14. C, Two-tailed unpaired t test, n = 7 per group, *p < 0.05 (p = 0.0322), t values (t = 2.423). D, Two-way ANOVA/Fisher's LSD test, n = 8 per group, *p < 0.05 (p = 0.0195), t values (t = 2.479) at day 3.