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. Author manuscript; available in PMC: 2021 Mar 15.
Published in final edited form as: Acta Biomater. 2020 Jan 23;105:203–213. doi: 10.1016/j.actbio.2020.01.033

Fig. 8.

Fig. 8.

Dexamethasone-induced responses to outflow in HTM/HSC and HTM/ADSC-derived HSC-like constructs after 3 (A) and 7 days (B) of treatment. Confocal images of expression of HSC marker and ECM protein in the HSC or ADSC-derived HSC-like cell layer of the co-cultured constructs with or without 7-day dexamethasone treatment. Expression of HSC marker PROX1 (C, D, E, F) and ECM protein of Collagen IV and fibronectin (G, H, I, J). Constructs were co-stained with vimentin (C, D, E, F) and F-actin (C, D, E, F, G, H, I, J) as well as DAPI to label nuclei. Scale bar = 50 μm. (K) Quantification of nuclear size after dexamethasone treatment compared to control. *p < 0.01, **p < 0.001, ***p < 0.0005.