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. Author manuscript; available in PMC: 2020 Nov 19.
Published in final edited form as: Acc Chem Res. 2019 Oct 8;52(11):3039–3050. doi: 10.1021/acs.accounts.9b00391

Figure 2.

Figure 2.

Bioluminescent probes for multi-component imaging. (A) Parallel engineering of luciferase enzymes and luciferin analogs to generate orthogonal pairs. A computational algorithm assists in the search for compatible imaging probes. (B) Sample classes of luciferin analogs targeted for orthogonal probe development. Blue, magenta, and teal dots represent unique modifications to the luciferin core. Part (A) was adapted with permission from ref. 67. Copyright 2017 American Chemical Society.