Table II.
Relative abundance (in %) of different taxonomic groups detected in the real-life test dataset using the GG-UCLUST and 16S-Udb-mothur approaches. Data are shown separately for healthy subjects and those with disease
| Taxonomic group | Subject group | 16S rRNA database and classifier algorithm used | |||||
|---|---|---|---|---|---|---|---|
| Greengenes-UCLUST | 16S-UDb-mothur | ||||||
| Median | Minimum | Maximum | Median | Minimum | Maximum | ||
| p_Bacteroidetes; f_Prevotellaceae; g_Prevotella; s_copri | Healthy | 58.17 | 0.79 | 77.16 | 58.2 | 0.78 | 77.53 |
| Patient | 8.92 | 0.02 | 67.53 | 8.87 | 0.02 | 67.81 | |
| p_Bacteroidetes; f_Prevotellaceae; g_Prevotella; s_stercorea | Healthy | 3.86 | 0.03 | 15.7 | 3.83 | 0.03 | 15.63 |
| Patient | 0.08 | 1.16E-03 | 17.93 | 0.08 | 1.16E-03 | 18.81 | |
| p_Firmicutes; f_Veillonellaceae; g_Mitsuokella; s_multacida | Healthy | 0.19 | 0 | 1.04 | 0.22 | 6.02E-04 | 1.05 |
| Patient | 1.75E-03 | 0 | 1 | 1.74E-03 | 0 | 1.06 | |
| p_Firmicutes; f_Erysipelotrichaceae; g_Eubacterium; s_biforme | Healthy | 0.12 | 3.99E-04 | 3.85 | 0.12 | 3.96E-04 | 3.91 |
| Patient | 0.08 | 0 | 5.62 | 0.08 | 0 | 5.59 | |
| p_Proteobacteria; f_Pasteurellaceae; g_Haemophilus; s_parainfluenzae | Healthy | 0.1 | 9.65E-04 | 2.98 | 0.1 | 9.75E-04 | 2.99 |
| Patient | 0.06 | 1.86E-03 | 7.75 | 0.06 | 1.85E-03 | 7.76 | |
| p_Firmicutes; f_Lactobacillaceae; g_Lactobacillus; s_ruminis | Healthy | 0.1 | 4.82E-04 | 5.7 | 0.1 | 4.88E-04 | 5.67 |
| Patient | 0.02 | 0 | 2.4 | 0.02 | 0 | 2.39 | |
| p_Firmicutes; f_Ruminococcaceae; g_Faecalibacterium; s_prausnitzii | Healthy | 0.09 | 0.02 | 0.62 | 3.33 | 0.51 | 9.19 |
| Patient | 0.13 | 1.05E-03 | 1.84 | 4.39 | 0.07 | 79.55 | |
| p_Actinobacteria; f_Coriobacteriaceae; g_Collinsella; s_aerofaciens | Healthy | 0.05 | 7.99E-04 | 16.22 | 0.05 | 7.93E-04 | 16.18 |
| Patient | 0.17 | 0 | 6.72 | 0.16 | 0 | 6.71 | |
| p_Actinobacteria; f_Bifidobacteriaceae; g_Bifidobacterium; s_adolescentis | Healthy | 0.05 | 0 | 8.4 | 0.05 | 1.84E-04 | 8.38 |
| Patient | 0.05 | 0 | 8.31 | 0.05 | 0 | 8.32 | |
| p_Firmicutes; f_Veillonellaceae; g_Veillonella; s_dispar | Healthy | 0.03 | 2.35E-03 | 2.85 | 0.03 | 9.75E-04 | 2.5 |
| Patient | 0.11 | 1.84E-03 | 3.04 | 0.08 | 1.60E-03 | 3 | |
| p_Actinobacteria; f_Bifidobacteriaceae; g_Bifidobacterium; s_longum | Healthy | 0.02 | 1.83E-03 | 3.14 | 0.02 | 1.84E-03 | 3.12 |
| Patient | 0.37 | 1.20E-03 | 34.4 | 0.37 | 1.20E-03 | 34.32 | |
| p_Firmicutes; f_Erysipelotrichaceae; g_Bulleidia; s_p-1630-c5 | Healthy | 0.02 | 0 | 0.22 | 0.02 | 0 | 0.22 |
| Patient | 2.54E-04 | 0 | 2.61 | 2.54E-04 | 0 | 2.59 | |
| p_Bacteroidetes; f_Porphyromonadaceae; g_Parabacteroides; s_distasonis | Healthy | 3.12E-03 | 0 | 0.56 | 3.22E-03 | 0 | 0.57 |
| Patient | 0.03 | 1.67E-04 | 7.87 | 0.03 | 1.66E-04 | 7.9 | |
| p_Bacteroidetes; f_Bacteroidaceae; g_Bacteroides; s_caccae | Healthy | 3.08E-03 | 0 | 0.45 | 3.27E-03 | 0 | 0.59 |
| Patient | 4.28E-03 | 0 | 15.76 | 0.03 | 0 | 15.86 | |
| p_Actinobacteria; f_Micrococcaceae; g_Rothia; s_mucilaginosa | Healthy | 1.31E-03 | 0 | 0.09 | 1.31E-03 | 0 | 0.09 |
| Patient | 2.98E-03 | 0 | 0.18 | 2.98E-03 | 0 | 0.17 | |
| p_Bacteroidetes; f_Bacteroidaceae; g_Bacteroides; s_fragilis | Healthy | 1.25E-03 | 0 | 0.07 | 1.25E-03 | 0 | 0.07 |
| Patient | 0.01 | 0 | 17.96 | 0.01 | 0 | 17.9 | |
| p_Firmicutes; f_Clostridiaceae; g_Clostridium; s_perfringens | Healthy | 8.10E-04 | 0 | 0.08 | 0 | 0 | 7.05E-04 |
| Patient | 2.84E-04 | 0 | 0.03 | 0 | 0 | 0.17 | |
| p_Proteobacteria; f_Pasteurellaceae; g_Actinobacillus; s_parahaemolyticus | Healthy | 6.58E-04 | 0 | 0.05 | 8.89E-04 | 0 | 0.05 |
| Patient | 1.73E-04 | 0 | 0.1 | 1.73E-04 | 0 | 0.12 | |
| p_Bacteroidetes; f_Bacteroidaceae; g_Bacteroides; s_plebeius | Healthy | 2.58E-04 | 0 | 0.99 | 2.59E-04 | 0 | 0.99 |
| Patient | 0.01 | 0 | 52.88 | 0.01 | 0 | 52.68 | |
| p_Firmicutes; f_Lactobacillaceae; g_Lactobacillus; s_mucosae | Healthy | 0 | 0 | 0.02 | 0 | 0 | 0.02 |
| Patient | 3.51E-04 | 0 | 0.45 | 3.48E-04 | 0 | 0.46 | |
| p_Actinobacteria; f_Coriobacteriaceae; g_Eggerthella; s_lenta | Healthy | 0 | 0 | 0.02 | 0 | 0 | 0.12 |
| Patient | 3.29E-04 | 0 | 0.75 | 1.04E-03 | 0 | 0.75 | |
| p_Firmicutes; f_Veillonellaceae; g_Veillonella; s_parvula | Healthy | 0 | 0 | 0.07 | 1.12E-03 | 0 | 0.41 |
| Patient | 2.71E-04 | 0 | 0.07 | 2.12E-03 | 0 | 0.11 | |
| p_Firmicutes; f_Erysipelotrichaceae; g_Eubacterium; s_dolichum | Healthy | 0 | 0 | 0.01 | 0 | 0 | 0.01 |
| Patient | 2.54E-04 | 0 | 0.02 | 2.54E-04 | 0 | 0.02 | |
| p_Firmicutes; f_Streptococcaceae; g_Streptococcus; s_anginosus | Healthy | 0 | 0 | 6.81E-04 | 0 | 0 | 6.81E-04 |
| Patient | 2.47E-04 | 0 | 0.05 | 2.46E-04 | 0 | 0.05 | |
| p_Bacteroidetes; f_Bacteroidaceae; g_Bacteroides; s_eggerthii | Healthy | 0 | 0 | 1.01E-03 | 0 | 0 | 1.00E-03 |
| Patient | 2.30E-04 | 0 | 2.52 | 2.29E-04 | 0 | 2.49 | |
| p_Firmicutes; f_Lachnospiraceae; g_Blautia; s_producta | Healthy | 0 | 0 | 0.01 | 0.03 | 2.12E-03 | 0.45 |
| Patient | 1.94E-04 | 0 | 0.16 | 0.03 | 3.90E-04 | 0.21 | |
| p_Firmicutes; f_Clostridiaceae; g_Clostridium; s_neonatale | Healthy | 0 | 0 | 0 | 0 | 0 | 2.25E-03 |
| Patient | 0 | 0 | 0.18 | 0 | 0 | 0.18 | |
| p_Proteobacteria; f_Oxalobacteraceae; g_Oxalobacter ; s_formigenes | Healthy | 0 | 0 | 0.01 | 2.10E-04 | 0 | 0.02 |
| Patient | 0 | 0 | 0.21 | 0 | 0 | 0.21 | |
| p_Proteobacteria; f_Enterobacteriaceae; g_Morganella; s_morganii | Healthy | 0 | 0 | 1.22E-03 | 0 | 0 | 1.20E-03 |
| Patient | 0 | 0 | 0.27 | 0 | 0 | 0.26 | |
| p_Proteobacteria; f_Moraxellaceae; g_Acinetobacter; s_johnsonii | Healthy | 0 | 0 | 2.36E-03 | 0 | 0 | 2.34E-03 |
| Patient | 0 | 0 | 0.09 | 0 | 0 | 0.09 | |
| p_Proteobacteria; f_Moraxellaceae; g_Acinetobacter; s_lwoffii | Healthy | 0 | 0 | 2.30E-03 | 0 | 0 | 2.29E-03 |
| Patient | 0 | 0 | 0.55 | 0 | 0 | 0.55 | |
| p_Verrucomicrobia; f_Verrucomicrobiaceae; g_Akkermansia; s_muciniphila | Healthy | 0 | 0 | 0.01 | 0 | 0 | 0.01 |
| Patient | 0 | 0 | 0.69 | 0 | 0 | 0.69 | |