| Methods |
Prospective, controlled, randomized, open, single centre study. |
| Participants |
All patients admitted to the hospital ICU with serum albumin less than or equal to 30g/L/. Exclusion criteria were expected length of stay <72 hrs., life expectancy <3 months or a do not resuscitate order, albumin administration in the preceding 24 hrs. or evidence of fluid overload. |
| Interventions |
1) Intervention (n=50) received 300 mL of 20% albumin solution on day 1 and 200 mL on subsequent days when serum albumin concentration was lower than 31 g/L.
2) Control (n=50) received Ringer's Lactate. |
| Outcomes |
Effect of albumin on organ function as assessed by a delta Sequential Organ Failure Assessment score. Deaths not reported. |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Low risk |
"Eligible patients were randomized in a 1:1 ratio using sealed envelopes. When a patient was assigned to one group, he or she remained in that group whether or not he or she received the planned treatment." |
