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. 2011 Nov 9;2011(11):CD001208. doi: 10.1002/14651858.CD001208.pub4

Brown 1988.

Methods Randomised controlled trial. Patients entered into the study were assigned to one of two treatment groups by a table of random numbers. Method of allocation concealment not described. Author contacted ‐ no allocation concealment.
Participants All patients who required central TPN and had hypoalbuminaemia (serum albumin concentration below 3.0g/dl). Patients who were thermally injured, had nephrotic syndrome or required protein restriction were excluded.
Interventions 1) The intervention group received central TPN plus normal serum albumin (n=33). 
 2) The control group (n=34) received central TPN alone.
Outcomes Deaths reported.
Notes Follow‐up to discharge.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) High risk