Brown 1988.
Methods | Randomised controlled trial. Patients entered into the study were assigned to one of two treatment groups by a table of random numbers. Method of allocation concealment not described. Author contacted ‐ no allocation concealment. | |
Participants | All patients who required central TPN and had hypoalbuminaemia (serum albumin concentration below 3.0g/dl). Patients who were thermally injured, had nephrotic syndrome or required protein restriction were excluded. | |
Interventions | 1) The intervention group received central TPN plus normal serum albumin (n=33). 2) The control group (n=34) received central TPN alone. | |
Outcomes | Deaths reported. | |
Notes | Follow‐up to discharge. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment (selection bias) | High risk |