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. 2009 Oct 7;2009(4):CD001246. doi: 10.1002/14651858.CD001246.pub2

STAMI.

Methods R= randomised but method not stated 
 C = not stated 
 Blinding: patients, clinicians and outcome assessors 
 Patients allocated to indistinguishable blister packs containing either ticlopidine or aspirin
Participants Multicentre, number not stated 
 1470 patients randomised 
 > 18 years old with MI (treated with thrombolytic therapy) ≤ 30 days before randomisation 
 Mean age: 59 years 
 Gender: 84% male 
 Race: not stated 
 Comparibility of groups: age, gender, vascular risk factors 
 Ex crit: contraindications to the study drugs including haemopoietic or haemostatic disorders, Hx thrombocytopenia, leucopenia or peptic ulcer, need for oral anticoagulant therapy, scheduled major or bypass surgery, severe co‐morbidity likely to limit life‐expectancy, uncontrolled hypertension, geographic or other factors likely to make participation impractical
Interventions Ticlopidine 250 mg twice daily versus aspirin 80 mg twice daily
Outcomes Primary: non‐fatal MI, non‐fatal stroke, angina with objective evidence of cardiac ischaemia, vascular death 
 Secondary: vascular death, non‐vascular death, non‐fatal stroke, non‐fatal MI, angina
Notes Co: 333 (22.6%) patients permanently discontinued the study drug early; 152 in the aspirin group and 181 in the ticlopidine group 
 Reasons for stopping the treatment early were adverse events (35 in aspirin group and 53 in ticlopidine group) 
 Of these, 26 in the aspirin group and 21 in the ticlopidine group withdrew because of occurrence of a primary end point 
 Duration of follow up: mean follow up was 6 months 
 Lost to follow up: 32 (4.4%) in the ticlopidine group and 30 (4.1%) in the aspirin group

B: blood pressure 
 C: concealment of allocation 
 Co: compliance 
 Ex crit: exclusion criteria 
 GI: gastrointestinal 
 Hx: history 
 MI: myocardial infarction 
 R: randomisation method 
 RIND: reversible ischaemic neurological deficit 
 Rx: treatment 
 SAH: subarachnoid haemorrhage 
 TIA: transient ischaemic attack