Study	Reason for exclusion
Abe 1981	Outcome measure (platelet aggregation) was not a serious vascular event
Akyuz 1999	Non‐randomised and outcome measure (platelet aggregation) was not a serious vascular event
Apollonio 1989	Non‐randomised Comparison confounded for question of interest (ticlopidine and pentoxifylline versus aspirin, dipyridamole and buflomedil versus buflomedil)
Aramendi 1998	Non‐randomised
Bergamasco 1997	Ticlopidine compared with indobufen, not aspirin
Cooke 2006	Outcome measures (platelet function) were not serious vascular events; follow up only 10 days
Dorr 2004	Outcome measures (platelet glycoprotein expression and aggregation) were not serious vascular events
Droste 1996	Duration of treatment was only 2 weeks (with cross over to 2 weeks of treatment with the alternative agent), and outcomes (haematological parameters, and asymptomatic cerebral emboli detected by transcranial doppler) were not important vascular events
Eder 2007	Outcome measure (platelet function) not serious vascular events
Fork 2000	Outcome measure (detection of macroscopic differences in the gastric mucosa) was not a serious vascular event
Jagroop 2004	Outcome measures (platelet function indices) were not serious vascular events
Kindsvater 2003	Outome measure exercise tolerance, not serious vascular events; follow up several hours only
KTS 1999	Uncertain if randomised Presumably healthy participants
Lim 2004	Primary outcome measure (platelet aggregation) was not a serious vascular event
Nomura 1996	Outcome measure (platelet aggregation) was not a serious vascular event
Ozalp 1997	Uncertain if randomised; outcome measure (plasma fibrinogen) not a serious vascular event
Rebrov 2001	Outcome measures (haemostasis and platelet aggregation) were not serious vascular events
Rey 1996	Not randomised
Rupprecht 1998	Outcome measure (platelet aggregation) not serious vascular events; follow up for 14 days only
Singh 1999	Outcome measure (platelet aggregation) not serious outcome events; follow up 10 days only
Tokyo 1993	Comparison confounded for question of interest (ticlopidine versus ticlopidine plus aspirin)
Vyshlov 2000	Outcome measures (platelet aggregation) not serious vascular events; follow up only 21 days
Woodward 2004	Outcome measures (clotting factors and C reactive protein) were not serious vascular events
Zucca 1992	Not randomised Outcome measure (carotid restenosis demonstrated by carotid doppler) not a serious vascular event