1 Death |
6 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
1.1 All |
6 |
248 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.35 [0.71, 2.56] |
1.2 Postnatal age < 24 hours |
4 |
167 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.47 [0.72, 2.97] |
1.3 Postnatal age at least 24 hours |
2 |
81 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.97 [0.21, 4.48] |
1.4 Loop diuretics |
5 |
198 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.30 [0.67, 2.52] |
1.5 Theophylline |
1 |
50 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.0 [0.19, 20.67] |
1.6 Sensitivity |
5 |
228 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.07 [0.51, 2.24] |
2 Clinically significant PDA |
4 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
2.1 All |
4 |
208 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.11 [0.72, 1.71] |
2.2 Postnatal age < 24 hours |
3 |
139 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.86 [0.50, 1.48] |
2.3 Postnatal age at least 24 hours |
1 |
69 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.7 [0.82, 3.53] |
2.4 Loop diuretics |
3 |
161 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.08 [0.67, 1.73] |
2.5 Theophylline |
1 |
47 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.25 [0.44, 3.54] |
3 Hypovolemic shock |
1 |
12 |
Risk Ratio (M‐H, Fixed, 95% CI) |
4.0 [0.20, 82.01] |
3.1 Postnatal age at least 24 hours |
1 |
12 |
Risk Ratio (M‐H, Fixed, 95% CI) |
4.0 [0.20, 82.01] |
4 Change in plasma volume (ml/kg) from 48 to 96 hours of life |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
‐7.7 [‐11.74, ‐3.66] |
4.1 Postnatal age at least 24 hours |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
‐7.7 [‐11.74, ‐3.66] |
5 Change in cardiovascular stability index from 48 to 96 hours of life |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
0.77 [‐0.14, 1.68] |
5.1 Postnatal age at least 24 hours |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
0.77 [‐0.14, 1.68] |
6 Dobutamine infusion rate (micrograms/kg/min) at the end of treatment |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
3.10 [‐0.62, 6.82] |
6.1 Postnatal age at least 24 hours |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
3.10 [‐0.62, 6.82] |
7 Dopamine infusion rate (micrograms/kg/min) at the end of treatment |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
2.41 [‐0.07, 4.89] |
7.1 Postnatal age at least 24 hours |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
2.41 [‐0.07, 4.89] |
8 Change in colloid infusion rate (ml/kg/hour) at the end of treatment |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.86 [‐4.30, 2.58] |
8.1 Postnatal age at least 24 hours |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.86 [‐4.30, 2.58] |
9 Failure to extubate within 3 days after study entry |
1 |
56 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.65 [0.45, 0.93] |
9.1 Postnatal age < 24 hours |
1 |
56 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.65 [0.45, 0.93] |
10 Change in peak inspiratory pressure (cm H2O) during treatment |
1 |
36 |
Mean Difference (IV, Fixed, 95% CI) |
‐6.62 [‐14.74, 1.50] |
10.1 Postnatal age < 24 hours |
1 |
36 |
Mean Difference (IV, Fixed, 95% CI) |
‐6.62 [‐14.74, 1.50] |
11 Change in mean airway pressure (cm H2O) during treatment |
2 |
125 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.16 [‐2.42, 0.09] |
11.1 Postnatal age < 24 hours |
1 |
56 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.30 [‐2.81, 0.21] |
11.2 Postnatal age at least 24 hours |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.85 [‐3.11, 1.41] |
12 Duration of mechanical ventilation (days) |
2 |
105 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.83 [‐4.49, ‐1.17] |
12.1 Postnatal age < 24 hours |
1 |
36 |
Mean Difference (IV, Fixed, 95% CI) |
‐5.0 [‐7.06, ‐2.94] |
12.2 Postnatal age at least 24 hours |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
1.20 [‐1.61, 4.01] |
13 Change in FiO2 during treatment |
2 |
92 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.05 [‐0.13, 0.03] |
13.1 Postnatal age < 24 hours |
2 |
92 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.05 [‐0.13, 0.03] |
14 Change in alveolar‐arterial O2 gradient (mm Hg) during treatment |
3 |
161 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.62 [‐43.75, 40.51] |
14.1 Postnatal age < 24 hours |
2 |
92 |
Mean Difference (IV, Fixed, 95% CI) |
‐66.81 [‐131.24, ‐2.37] |
14.2 Postnatal age at least 24 hours |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
47.06 [‐8.62, 102.74] |
15 BPD |
3 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
15.1 All |
3 |
139 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.81 [0.41, 1.59] |
15.2 Postnatal age < 24 hours |
3 |
139 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.81 [0.41, 1.59] |
15.3 Loop diuretics |
2 |
92 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.02 [0.49, 2.10] |
15.4 Theophylline |
1 |
50 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.29 [0.04, 2.44] |
16 Death or BPD |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
16.1 All |
2 |
87 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.95 [0.32, 2.76] |
16.2 Postnatal age <24 hours |
2 |
87 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.95 [0.32, 2.76] |
16.3 Loop diuretics |
1 |
37 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.55 [0.29, 22.31] |
16.4 Theophylline |
1 |
50 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.6 [0.16, 2.25] |
17 Duration of oxygen supplementation (days) |
3 |
161 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.50 [‐2.51, 1.50] |
17.1 Postnatal age < 24 hours |
2 |
92 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.22 [‐2.40, 1.96] |
17.2 Postnatal age at least 24 hours |
1 |
69 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.10 [‐7.28, 3.08] |
18 IVH |
3 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
18.1 All |
3 |
127 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.76 [0.40, 1.44] |
18.2 Postnatal age < 24 hours |
3 |
127 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.76 [0.40, 1.44] |
18.3 Loop diuretics |
2 |
80 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.90 [0.43, 1.88] |
18.4 Theophylline |
1 |
47 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.52 [0.15, 1.84] |
18.5 Sensitivity |
2 |
107 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.63 [0.32, 1.26] |
19 Severe IVH (grade III or IV) |
1 |
47 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.04 [0.07, 15.72] |
19.1 All studies |
1 |
47 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.04 [0.07, 15.72] |
20 Duration of hospitalization (days) |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
20.1 All |
2 |
103 |
Mean Difference (IV, Fixed, 95% CI) |
2.43 [‐10.71, 15.57] |
20.2 Postnatal age < 24 hours |
2 |
103 |
Mean Difference (IV, Fixed, 95% CI) |
2.43 [‐10.71, 15.57] |
20.3 Loop diuretics |
1 |
56 |
Mean Difference (IV, Fixed, 95% CI) |
6.60 [‐16.38, 29.58] |
20.4 Theophylline |
1 |
47 |
Mean Difference (IV, Fixed, 95% CI) |
0.40 [‐15.62, 16.42] |
21 Significant handicap at one year (major neurologic defect and/or MDI/PDI <50) |
1 |
26 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.43 [0.09, 1.94] |
21.1 Postnatal age < 24 hours |
1 |
26 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.43 [0.09, 1.94] |
22 Oligoanuria (urine output < 1 ml/kg/hour) |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
22.1 All |
1 |
47 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.13 [0.02, 0.96] |
22.2 Theophylline |
1 |
47 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.13 [0.02, 0.96] |
23 Hyponatremia (sodium < 130 mM/L) |
1 |
47 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.04 [0.16, 6.80] |
23.1 All |
1 |
47 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.04 [0.16, 6.80] |
24 Hyperkalemia (potassium > 6.5 mM/L) |
1 |
47 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.57 [0.29, 8.53] |
24.1 All |
1 |
47 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.57 [0.29, 8.53] |