Table 1.
Assays results summary: percentage of active chemicals computed based on the 8,305 chemicals tested from Tox21.
| Assays | Cell culture | Type of AC50/IC50 | # of actives post-filtering | % active | Mean, SD AC50/IC50 (µM) |
|---|---|---|---|---|---|
| Luciferase | Luciferase | 552 | 6.6 | 28.3 +/− 19.1 | |
| Auto-fluorescence | HepG2 | Cell based blue | 216 | 2.6 | 19.8 +/− 14.5 |
| Cell based green | 80 | 0.9 | 22.1 +/− 16.2 | ||
| Cell based red | 39 | 0.5 | 16.5 +/− 13.0 | ||
| Cell free blue | 209 | 2.5 | 21.5 +/− 14.3 | ||
| Cell free green | 80 | 0.9 | 19.5 +/− 12.1 | ||
| Cell free red | 37 | 0.4 | 20.5 +/− 14.8 | ||
| HEK-293 | Cell based blue | 210 | 2.5 | 22.3 +/− 13.6 | |
| Cell based green | 56 | 0.7 | 20.0 +/− 13.0 | ||
| Cell based red | 33 | 0.4 | 18.7 +/− 13.9 | ||
| Cell free blue | 224 | 2.7 | 20.7 +/− 13.8 | ||
| Cell free green | 44 | 0.5 | 19.0 +/− 16.1 | ||
| Cell free red | 34 | 0.4 | 19.2 +/− 12.9 |