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. 2020 Mar 4;10:4000. doi: 10.1038/s41598-020-60785-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of CXCR2 with SB225002 and anti-oxidant suppressed the change of EMT markers induced by TGF-β2 and H₂O₂ in ARPE-19 cells. (a) SB225002 (1.0 µM) inhibited the TGF-β2-induced protein expression of Snail, Slug and E-cad. (b) The over-expression of α-SMA induced by 200 µM H₂O₂ was inhibited by 1.0 µM SB225002. (c) The TGF-β2 (20 ng/mL)-induced α-SMA protein expression was inhibited by both anti-oxidant N-acetyl-L-cysteine (NAC) and 1.0 µM SB225002. (Results of 3 repeated experiments; *p < 0.05; **p < 0.01; ***p < 0.001).