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. 2020 Mar 4;10:4023. doi: 10.1038/s41598-020-60773-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Disaggregation of pre-formed Tau aggregates by basic limonoids. (A,B) The role of basic limonoids in disaggregation of Tau was analysed by ThS and ANS fluorescence assay. The ThS and ANS fluorescence were evidenced to increase at 144 hours. This indicated that limonoids have no role in solubilizing the preformed Tau aggregates. (C) The aggregates of Tau exhibited the morphology of extended and thick filaments in the absence of limonoids. (D) Epoxyazadiradione destabilizes the pre-formed aggregates to shorter fragments. (E,F) Azadirone and gedunin altered the morphology of Tau aggregates and disintegrated them into shorter filaments. (G) Azadiradione completely destabilized Tau aggregates. The graph was plotted using SigmaPlot 10.0, from Systat Software, Inc., San Jose California USA, www.systatsoftware.com.