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. 2020 Mar 4;10:4023. doi: 10.1038/s41598-020-60773-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hsp70 levels aggravated on epoxyazadiradione treatment. (A) Hsp70, an indispensable chaperone involved in proteotoxic stress, its levels are increased when cells are exposed to Tau. (B) Tau aggregates increased the Hsp70 level in HEK293T cells as compared to cell control where the cells showed an extended morphology. (C) Epoxyazadiradione alone and together with Tau aggregates have increased the cellular Hsp70 levels, which indicates the induction of cellular proteostasis machinery in the context of extracellular protein burden. Quantification was carried out by Zen 2.3 software (https://www.zeiss.com/microscopy/int/products/light-microscopes/axio-observer-for-biology.html).