Table 3.
Pathways dysregulated in the Dys−/− retina – microT-CDS prediction.
| KEGG pathway | p-value | #genes | #miRNAs |
|---|---|---|---|
| Prion diseases | 1.44E-17 | 3 | 3 |
| MAPK signaling pathway | 2.68E-07 | 58 | 6 |
| Axon guidance | 0.000285 | 32 | 6 |
| Endocytosis | 0.000792 | 38 | 6 |
| Long-term potentiation | 0.001331 | 20 | 5 |
| Rap1 signaling pathway | 0.001331 | 41 | 6 |
| Thyroid hormone signaling pathway | 0.001403 | 23 | 6 |
| Oxytocin signaling pathway | 0.001742 | 32 | 6 |
| mRNA surveillance pathway | 0.002901 | 22 | 6 |
| Calcium signaling pathway | 0.003031 | 35 | 6 |
| mTOR signaling pathway | 0.00307 | 18 | 6 |
| Fatty acid elongation | 0.015193 | 4 | 3 |
| Glutamatergic synapse | 0.015193 | 21 | 5 |
| HTLV-I infection | 0.015193 | 47 | 6 |
| Adherens junction | 0.017904 | 15 | 6 |
| cGMP-PKG signaling pathway | 0.017904 | 33 | 6 |
| FoxO signaling pathway | 0.017904 | 30 | 6 |
| Wnt signaling pathway | 0.020194 | 28 | 6 |
| cAMP signaling pathway | 0.022403 | 37 | 6 |
| T cell receptor signaling pathway | 0.022579 | 22 | 6 |
| Ubiquitin mediated proteolysis | 0.024099 | 29 | 6 |
| VEGF signaling pathway | 0.024486 | 15 | 5 |
| Insulin signaling pathway | 0.024486 | 28 | 6 |
| Bacterial invasion of epithelial cells | 0.024486 | 17 | 6 |
| Transcriptional misregulation in cancer | 0.026035 | 31 | 6 |
| Neurotrophin signaling pathway | 0.026125 | 24 | 6 |
| Vasopressin-regulated water reabsorption | 0.026702 | 8 | 6 |
| Amyotrophic lateral sclerosis (ALS) | 0.026758 | 13 | 6 |
| Protein processing in endoplasmic reticulum | 0.034352 | 29 | 6 |
| Amphetamine addiction | 0.040134 | 15 | 4 |
| AMPK signaling pathway | 0.041784 | 24 | 6 |
| TGF-beta signaling pathway | 0.041784 | 20 | 5 |
| Circadian entrainment | 0.045922 | 18 | 6 |