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. 2020 Mar 4;11:1193. doi: 10.1038/s41467-020-15056-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Genetic diagram of the iSLC strain. b Simulations of the mathematical model showing three different dynamics at low (blue), medium (orange) and high (purple) inducer values. Medium values are predicted to result in sustained oscillations. Left: steady state maximum and minimum cell population values are plotted for a range of inducer concentrations. Right: simulated time traces for three representative p-coumaric acid values predict three emergent population dynamics. c Comparison between the iSLC and SLC dynamics based upon the model simulations in part b. d Diagram of the microfluidic device used to generate the inducer gradient. e Heatmaps representing the fluorescence time traces of all 14 traps present per column of the device. GFP signal is used as a proxy for population density. Four different inducer conditions are shown: low, medium, high, extra high, respectively. f Top: representative time series images from the fluorescence channel with three different inducer concentrations: low, medium, high, respectively. Bottom: fluorescence time traces plotted together with computer simulations of the mathematical model. For the simulation (dashed lines) time units are arbitrary, therefore the correspondence is strictly qualitative. Source data are provided as a Source Data file.