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. 2020 Mar 4;10:3982. doi: 10.1038/s41598-020-60939-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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An LXCXE motif-containing protein disrupts RB interactions with negative epigenetic regulators of E2F signaling, but not RB-E2F interactions. (a) A kinetic surface plasmon resonance binding curve (sensorgram) of full-length HDAC1 to the RB pocket domain is shown. (b) Kinetic binding curve of full-length HDAC1 in competition with full-length TpMuguga02_00667 (TpGcpE). (c) A sensorgram of full-length E2F1 to the RB pocket domain is shown. (d) Kinetic binding curve of full-length E2F1 in competition with full-length TpMuguga02_00667. (e) Western blot analysis of RB and HDAC1 in BL20 and TBL20 cells. (f) Co-immunoprecipitation of RB and HDAC1 in RB immunoprecipitates. Shown is a representative of three independent experiments.