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. 2020 Mar 4;10:3974. doi: 10.1038/s41598-020-60212-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ROC curves and AUC of EV-miRNA expression in mCRC identification: (A) Receiver Operating Characteristics (ROC) curves and AUC of baseline EVs miR-19b, 21, 222, 92a and CEA, adjusted by age and gender, according to metastatic colorectal cancer (mCRC) identification. Shaded areas show the increased sensitivity and specificity of each miRNA vs. the CEA curve. (B) Histogram representing the AUC of each miRNA and their statistical differences with baseline CEA. miR-21 and miR-92 were the best predictors in the identification of mCRC with higher sensitivity and specificity than baseline CEA, while miR-222 showed no statistical differences and 19b had lower sensitivity and specificity than CEA. Data are presented as histogram of the mean with the standard error bars. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns: no significant differences.