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. 2020 Feb 26;11:230. doi: 10.3389/fimmu.2020.00230

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Copyright © 2020 Makinde, Winter, Procissi, Mike, Stock, Kando, Gadhvi, Droho, Bloomfield, Dominguez, Mayr, Lavine, Putterman and Cuda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evidence of diffuse leukocyte infiltration in CReCOM brains. Brains of 11-12-month-old female WT (n = 4) and CReCOM (n = 4) mice were split into two portions and analyzed by flow cytometry. Data are representative of three independent experiments. (A) Whole brain gating strategy. (B) Regional breakdown for subsequent analysis. (C) Analysis of cortical region infiltration of T-cells (CD4⁺CD45^hi and CD8⁺CD45^hi), B-cells (CD19⁺CD45^hi), neutrophils (CD11b⁺Ly6G⁺CD45^hi), NK cells (CD11b⁺NK1.1⁺CD45^hi), macrophages (CD11b⁺CD64⁺CD45^hi), monocytes (CD11b⁺CD64⁻CD45^hi), as well as microglia (CD11b⁺CD64⁺CD45^lo). (D) Analysis of aforementioned populations in cerebellar region (*p < 0.05).