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. 2020 Feb 25;147(4):dev181693. doi: 10.1242/dev.181693

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© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Perturbing oestrogen levels at embryonic D7-7.5 (HH31) affects cortex formation in ZW and ZZ embryos. (A-H) Sections from left gonads at D10 (HH36) (A-D) or D17 (HH43) (E-H) double-stained for the Sertoli marker SOX9 (red) and a germ cell marker (VASA or P63; green) in ZW controls (A,E), ZZ controls (B,F), ZW gonads treated with fadrozole (ZW-Fa) (C,G) and ZZ gonads treated with β-oestradiol (ZZ-E2) (D,H). Decreasing oestrogen in ZW embryos after sex determination compromises the differentiation of the ovarian cortex; adding β-oestradiol in ZZ embryos after sex determination induces the formation of a cortex on top of a male medulla. White dotted lines highlight the cortex-medulla border.