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Overcoming the stratum corneum with particle-based systems and targeting of the APC network in the skin. Particle-based systems for transdermal vaccine delivery facilitate the targeting of the versatile network of skin-resident antigen-presenting cells (APCs). Activated APCs incorporate an antigen and migrate to the draining lymph node (dLN) where naive T cells are primed, thereby enabling an antigen-specific cellular immune response.
